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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPP2CA All Species: 51.52
Human Site: T301 Identified Species: 75.56
UniProt: P67775 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P67775 NP_002706.1 309 35594 T301 R R G E P H V T R R T P D Y F
Chimpanzee Pan troglodytes XP_527011 309 35630 T301 R R G E P H V T R R T P D Y F
Rhesus Macaque Macaca mulatta XP_001084083 286 32771 D279 Q A A I M E L D D T L K Y S L
Dog Lupus familis XP_858531 311 35711 T303 R R G E P H V T R R T P D Y F
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus P63331 309 35590 T301 R R G E P H V T R R T P D Y F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512852 302 34248 T294 R R G E P H V T R R T P D Y F
Chicken Gallus gallus P48463 309 35545 T301 R R G E P H V T R R T P D Y F
Frog Xenopus laevis Q6IP91 307 35104 S298 Q E T R G I P S K K P V A D Y
Zebra Danio Brachydanio rerio A8WGP3 311 35438 S302 Q E T R G L P S K K P V A D Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P23696 309 35450 T301 R R G E P H V T R R T P D Y F
Honey Bee Apis mellifera XP_623105 309 35425 T301 R R G E P H V T R R T P D Y F
Nematode Worm Caenorhab. elegans Q9XW79 333 37341 K325 E N R G A P A K K P H A D Y F
Sea Urchin Strong. purpuratus XP_780423 308 35412 T300 R R G E P H V T R R T P D Y F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q07100 313 35814 T305 R R G E P D V T R R T P D Y F
Baker's Yeast Sacchar. cerevisiae P23595 377 43028 T369 R P G E P T V T R K T P D Y F
Red Bread Mold Neurospora crassa P48580 327 37273 S319 R A G E P M V S R R T P D Y F
Conservation
Percent
Protein Identity: 100 99 89.9 96.7 N.A. N.A. 99.6 N.A. 90.9 98 66 64.6 N.A. 93.8 96.1 59.1 93.5
Protein Similarity: 100 99 91.9 98.7 N.A. N.A. 100 N.A. 93.1 99 81.5 81 N.A. 98.7 98 74.7 96.7
P-Site Identity: 100 100 0 100 N.A. N.A. 100 N.A. 100 100 0 0 N.A. 100 100 20 100
P-Site Similarity: 100 100 13.3 100 N.A. N.A. 100 N.A. 100 100 33.3 33.3 N.A. 100 100 26.6 100
Percent
Protein Identity: N.A. N.A. N.A. 78.5 62.6 81.3
Protein Similarity: N.A. N.A. N.A. 87.2 71.8 86.8
P-Site Identity: N.A. N.A. N.A. 93.3 80 80
P-Site Similarity: N.A. N.A. N.A. 93.3 86.6 86.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 13 7 0 7 0 7 0 0 0 0 7 13 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 7 0 7 7 0 0 0 82 13 0 % D
% Glu: 7 13 0 75 0 7 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 82 % F
% Gly: 0 0 75 7 13 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 57 0 0 0 0 7 0 0 0 0 % H
% Ile: 0 0 0 7 0 7 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 7 19 19 0 7 0 0 0 % K
% Leu: 0 0 0 0 0 7 7 0 0 0 7 0 0 0 7 % L
% Met: 0 0 0 0 7 7 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 7 0 0 75 7 13 0 0 7 13 75 0 0 0 % P
% Gln: 19 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 75 63 7 13 0 0 0 0 75 69 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 19 0 0 0 0 0 7 0 % S
% Thr: 0 0 13 0 0 7 0 69 0 7 75 0 0 0 0 % T
% Val: 0 0 0 0 0 0 75 0 0 0 0 13 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 7 82 13 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _